Translational Nephrology Stem cell therapy for Alport syndrome: the hope beyond the hype∗
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چکیده
1Department of Nephrology & Rheumatology, University of Göttingen, Göttingen, Germany, 2Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN, USA, 3Department of Nephrology, Medical Policlinic, University of Munich, Munich, Germany, 4Division of Nephrology, The Hospital of Sick Children, University of Toronto, Toronto, Canada, 5Merheim Medical Center, University of Witten-Herdecke, Campus Cologne, Cologne, Germany, 6Clinic for Nephrology, USZ and Institute of Anatomy, University of Zurich, Switzerland, 7Nephrology Department, Fundacio Puigvert, Barcelona, Spain, 8Inserm U574, Universite Paris Descartes, 9Centre de Référence des Maladies Rénales Héréditaires de l’Enfant et de l’Adulte (MARHEA) Service de Néphrologie Pédiatrique, Hôpital Necker-Enfants Malades, Paris, France, 10Boys Town National Research Hospital, Omaha, NE, 11Department of Small Animal Clinical Sciences, Texas A & M University, College Station, TX, 12Division of Pediatric Nephrology, University of Minnesota, MN, 13Nephrology and Hypertension Division, Department of Internal Medicine, The University of Utah School of Medicine, UT, USA, 14Department of Medicine, The Northern Hospital, The University of Melbourne, Epping, Australia, 15Department of Pediatrics, Peking University, First Hospital, Beijing, China, 16Department of Laboratory Medicine, Hospital for Sick Children and University of Toronto, Toronto, Canada, 17Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS, USA, 18Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden and 19Renal Division, Washington University School of Medicine, St Louis, MO USA
منابع مشابه
Stem cell therapy for Alport syndrome: the hope beyond the hype.
Gross, O; Borza, D B ; Andres, H J; Licht, C; Weber, M; Segerer, S; Torra, R; Gubler, M C; Heidet, L; Harvey, S; Cosgrove, D; Lees, G; Kashtan, C; Gregory, M; Savige, J; Ding, J; Thorner, P; Abrahamson, D R ; Antignac, C; Tryggvason, K ; Hudson, B; Miner, J H Gross, O; Borza, D B; Andres, H J; Licht, C; Weber, M; Segerer, S; Torra, R; Gubler, M C; Heidet, L; Harvey, S; Cosgrove, D; Lees, G; Kas...
متن کاملStem cell therapies benefit Alport syndrome.
Patients with Alport syndrome progressively lose renal function as a result of defective type IV collagen in their glomerular basement membrane. In mice lacking the alpha3 chain of type IV collagen (Col4A3 knockout mice), a model for Alport syndrome, transplantation of wild-type bone marrow repairs the renal disease. It is unknown whether cell-based therapies that do not require transplantation...
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The ability to culture human stem cells long term, and possibly indefinitely, and to control how such cells specialise to form the different tissues of the body offers the possibility of major advances in healthcare. Stem cells have been isolated and cultured, but a great deal of research is required to develop cell lines which can generate replacement cells and tissues to treat many diseases.S...
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© The Author 2013. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/ . ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 1 Stem cell therapy for Alzheimer’...
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s:3604:"During pregnancy, the placenta delivers "cord blood" to the baby through the umbilical cord serving as a lifeline of nourishment from the mother to baby. At birth, "cord blood" remains in the umbilical cord and placenta and until recently, had typically been discarded. The tragedy of this practice is that "cord blood" contains very special cells called "stem cells". Recent advances in m...
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تاریخ انتشار 2009